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In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate


Che Seman, Che Nor Zarida and Othman, Fauziah and Abdul Kadir, Arifah and Ahmad, Azfar Rizal and Yazid, Mohd Nazri and Zulkifly, Ahmad Hafiz and Mustaffa, Rusnah and Goriman Khan, Mohd Azam Khan and Saidi, Hasni Idayu (2011) In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate. African Journal of Pharmacy and Pharmacology, 5 (20). art. no. 9490DED32053. pp. 2283-2291. ISSN 1996-0816


This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by measuring the absorbance at 400 nm. The standard graphs for tobramycin and gentamicin concentration versus absorbance reading were prepared as references to identify the concentration of the drugs release after incorporating calcium phosphate over 8 weeks. This study showed that incorporating tobramycin and gentamicin with calcium phosphate provided slow residual release of antibiotic from 30 min to 1344 h (8 weeks) and dissolution of calcium phosphate. In this respect, the drug delivery systems of tobramycin and gentamicin-incorporated calcium phosphate have potential of controlling drug release.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.5897/AJPP11.591
Publisher: Academic Journals
Keywords: Calcium phosphate; Drug delivery system; Gentamicin; Osteomyelitis; Tobramycin
Depositing User: Nur Farahin Ramli
Date Deposited: 13 Sep 2013 03:48
Last Modified: 22 Apr 2016 06:58
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5897/AJPP11.591
URI: http://psasir.upm.edu.my/id/eprint/24744
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