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In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil.


Zakaria, Zainul Amiruddin and Somchit, Muhammad Nazrul and Mat Jais, Abdul Manan and Lay, Kek Teh and Salleh, Mohd Zaki and Long, Kamariah and Abdullah, Muhammad Nazrul Hakim (2011) In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. Medical Principles and Practice, 20 (3). pp. 231-236. ISSN 1011-7571; ESSN:1423-0151


Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1159/000323756
Publisher: Karger: Open Access Journals
Keywords: Virgin coconut oil; Antinociceptive; Anti-inflammatory; In vivo.
Depositing User: Nur Farahin Ramli
Date Deposited: 12 Sep 2013 04:46
Last Modified: 18 Nov 2015 03:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000323756
URI: http://psasir.upm.edu.my/id/eprint/24728
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