Three new amides from Streptomyces sp. H7372

Citation

Cheenpracha, Sarot and Borris, Robert P. and Tran, Tammy T. and Jee, Jap Meng and Seow, Heng Fong and Cheah, Hwen Yee and Ho, Coy Choke and Chang, Leng Chee (2011) Three new amides from Streptomyces sp. H7372. Journal of the Brazilian Chemical Society, 22 (2). pp. 223-229. ISSN 0103-5053; ESSN: 1678-4790

Abstract

Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His - and inactive on SD His + at 2.5 μg per disk, respectively.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1590/S0103-50532011000200006
Publisher:	Sociedade Brasileira de Química
Keywords:	Streptomyces sp.; Yeast two-hybrid screen; Ras-Raf-1 interaction; Amides
Depositing User:	Nur Farahin Ramli
Date Deposited:	12 Sep 2013 05:15
Last Modified:	02 Dec 2016 03:33
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1590/S0103-50532011000200006
URI:	http://psasir.upm.edu.my/id/eprint/24724
Statistic Details:	View Download Statistic

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