UPM Institutional Repository

The heritability of premenstrual syndrome


Jahanfar, Shayesteh and Lye, Munn Sann and S. Krishnarajah, Isthrinayagy (2011) The heritability of premenstrual syndrome. Twin Research and Human Genetics, 14 (5). pp. 433-436. ISSN 1832-4274; ESSN: 1839-2628


We aimed to determine (1) the prevalence of premenstrual syndrome in a sample of twins and (2) the relative contribution of genes and environment in premenstrual syndrome. A group of 193 subjects inclusive of same gender twins (n = 176) and females from opposite sex twin sets (n = 17) entered the study. Heritability analysis used same gender twin data only. The probandwise concordance rate for the presence or absence of premenstrual syndrome was calculated and the heritability of premenstrual syndrome was assessed by a quantitative genetic model fitting approach using MX software. The prevalence of premenstrual syndrome was 43.0% and 46.8% in monozygotic and dizygotic twins, respectively. The probandwise concordance for premenstrual syndrome was higher in monozygotic (0.81) than in dizygotic twins (0.67), indicating a strong genetic effect. Quantitative genetic modeling found that a model comprising of additive genetic (A) and unique environment (E) factors provided the best fit (A: 95%, E: 5%). No association was found between premenstrual symptom and the following variables: belonging to the opposite gender twin set, birth weight, being breast fed and vaccination. These results established a clear genetic influence in premenstrual syndrome.

Download File

Text (Abstract)
The heritability of premenstrual syndrome.pdf

Download (34kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
DOI Number: https://doi.org/10.1375/twin.14.5.433
Publisher: Cambridge University Press
Keywords: Heritability; Premenstrual; Twin
Depositing User: Nur Farahin Ramli
Date Deposited: 06 Sep 2013 08:12
Last Modified: 16 Oct 2018 02:16
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1375/twin.14.5.433
URI: http://psasir.upm.edu.my/id/eprint/24674
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item