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Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite.


Citation

Hussein Al Ali, Samer Hasan and Al-Qubaisi, Mothanna and Hussein, Mohd Zobir and Ismail, Maznah and Zainal, Zulkarnain and Abdullah, Muhammad Nazrul Hakim (2012) Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. International Journal of Nanomedicine, 7 (1). pp. 2129-2141. ISSN 1176-9114; ESSN:1178-2013

Abstract

The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated material can be used as a controlled-release formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 Å and 19.9 Å by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-release properties and can therefore be used as a controlled-release formulation.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.2147/IJN.S30461
Publisher: Dove Medical Press
Keywords: Controlled release; Angiotensin-converting enzyme; Inhibition properties; Antihypertensive drug; Perindopril erbumine; Layered double hydroxide; Nanocomposite.
Depositing User: Nur Farahin Ramli
Date Deposited: 20 Sep 2013 02:55
Last Modified: 14 Sep 2015 00:05
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S30461
URI: http://psasir.upm.edu.my/id/eprint/24618
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