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Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production


Yong, Yoke Keong and Abdul Kadir, Arifah and Sukardi, Sabrina and Abd Hamid @ Abdul Razak, Roslida and Somchit, Muhammad Nazrul and Ahmad, Zuraini (2011) Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production. Medical Principles and Practice, 20 (2). pp. 142-146. ISSN 1011-7571; ESSN: 1423-0151


Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay). Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg. Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1159/000319907
Publisher: Karger
Keywords: Anti-inflammatory; Bixa orellana; Bradykinin; Vascular permeability
Depositing User: Nur Farahin Ramli
Date Deposited: 19 Mar 2014 03:53
Last Modified: 28 Oct 2016 03:04
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000319907
URI: http://psasir.upm.edu.my/id/eprint/24585
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