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Aggressive variant large granular lymphocytic leukaemia: a case report


Md Noor, Sabariah and Seman, Zainina and Idris, Faridah and Leong, Chooi Fun (2011) Aggressive variant large granular lymphocytic leukaemia: a case report. Malaysian Journal of Medicine and Health Sciences, 7 (1). pp. 57-60. ISSN 1675-8544


Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt all standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: T-LGL; NK leukaemia; Treatment of aggressive variant leukaemia
Depositing User: Nur Farahin Ramli
Date Deposited: 24 Mar 2014 05:43
Last Modified: 08 Sep 2015 03:51
URI: http://psasir.upm.edu.my/id/eprint/24511
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