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Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats


Adam, Zainah and Ismail, Amin and Khamis, Shafii and Mohd Mokhtar, Muhammad Hanaffi and Hamid, Muhajir (2011) Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats. Sains Malaysiana, 40 (5). pp. 489-495. ISSN 0026-6039


Ficus deltoidea is one of the common medicinal plants used in Malaysia. This epiphytic plant, from the Moraceae family has been claimed to have antidiabetic property. However, scientific evidence to confirm its efficacy is still lacking. The present study was undertaken to evaluate the effect of ethanolic extract of F. deltoidea on glucose level in normal rats at different prandial state. The results showed that, all doses of ethanolic extract of F. deltoidea reduced fasting blood glucose particularly after 6 h of administration. Interestingly, the extract did not produce severe hypoglycemia as shown by its comparable effect with metformin. Likewise, postprandial hyperglycemia was also significantly reduced particularly after 4 and 6 h of administration. Furthermore, extract was used at a dose of 1000 mg/kg b.w., reduced postprandial hyperglycemia similar to metformin. This suggests that postprandial antihyperglycemic mechanism of this extract is mediated through enhancement of glucose uptake into muscle cells and reduction of hepatic gluconeogenesis. Glucose tolerance activity was also significantly improved in the presence of ethanolic extract of F. deltoidea. From this study, it is suggested that ethanolic extract of F. deltoidea reduced postprandial hyperglycemia and improves glucose tolerance activity in normal rats.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Biotechnology and Biomolecular Sciences
Publisher: Penerbit Universiti Kebangsaan Malaysia
Keywords: F. deltoidea; Glucose tolerance activity; Postprandial antihyperglycemia
Depositing User: Nur Farahin Ramli
Date Deposited: 30 Mar 2014 06:09
Last Modified: 16 Oct 2018 03:59
URI: http://psasir.upm.edu.my/id/eprint/24440
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