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Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis.


Citation

Ho, Wan Yong and Yeap, Swee Keong and Ho, Chai Ling and Abdul Rahim, Raha and Abd. Aziz, Suraini and Mohamed Alitheen, Noorjahan Banu (2011) Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. Journal of Medicinal Plants Research, 5 (24 ). pp. 5741-5749. ISSN 1996-0875

Abstract

Plants have not only been consumed as food but have also been adopted as folk medicine for centuries. Elephantopus scaber Linn, a herb from the Asteraceae family, has traditionally been taken as decoction or tea to cure various ailments and diseases throughout the world. Recent studies had also suggested that this plant posses various bioactivities such as anti-bacterial, anti-inflammatory, hepatoprotective as well as anti cancer properties. In this study, the cytotoxic effect of an ethanolic extract of E. scaber on a breast cancer cell line, MCF-7 and the underlying cell death mechanism was examined. E. scaber showed cytotoxic effect towards MCF-7 cells with an IC 50 value of 15 μg/mL. In comparison to the untreated control, the extract triggered cell death with increased phosphatidylserine externalization, DNA breaks and significant morphological apoptotic characteristics in the MCF-cells. Furthermore, we also found that expression of the tumor suppressor p53 protein was up-regulated in response to the treatment. In conclusion, these results suggested that the ethanolic extract of E. scaber may be a potential anti cancer agent for human breast cancer cells by the induction of p53-dependent apoptosis.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Publisher: Academic Journals
Keywords: Ethanol extract; MCF-7; Tumor suppressor protein; DNA fragmentation, Phosphatidylserine externalization.
Depositing User: Nur Farahin Ramli
Date Deposited: 22 Oct 2013 09:06
Last Modified: 14 Sep 2015 00:39
URI: http://psasir.upm.edu.my/id/eprint/24135
Statistic Details: View Download Statistic

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