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Evaluation of immunomodulatory effect: selection of the correct targets for immunostimulation study


Yeap, Swee Keong and Abd Rahman, Mashitoh and Mohammed Alitheen, Noorjahan Banu and Ho, Wan Yong and Omar, Abdul Rahman and Beh, Boon Kee and Ky, Huynh (2011) Evaluation of immunomodulatory effect: selection of the correct targets for immunostimulation study. American Journal of Immunology, 7 (2). pp. 17-23. ISSN 1553-619X; ESSN: 1558-3775


Problem statement: Numerous plants or remedies that are traditionally used for various diseases had been claimed to maintain general good health, particularly the immune system. With the advanced understanding on immunology and ethnopharmacology, study on the interaction of this herb with the immune system is critical to understand the safety and its efficacy as a potent immunomodulatory agent. Approach: Selecting proper immune cells from a suitable immune organ allowed for the understanding on the mode of immunomodulation. Lymphocytes isolated from mammalian thymus, spleen and bone marrow represented great candidates for this immunomodulatory study. Results: A number of herbal extracts including that of Rhaphidophora korthalsii and compounds isolated from this plant, namely lectin and zerumbone, had been identified as potent immunostimulators. Conclusion/Recommendations: Future studies are needed to elucidate the mechanism underlaying activites of these immunomodulatory agents.

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Official URL or Download Paper: http://thescipub.com/html/10.3844/ajisp.2011.17.23

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
DOI Number: https://doi.org/10.3844/ajisp.2011.17.23
Publisher: Science Publications
Keywords: Immunomodulation; Mitogen; PBMC; Spleen
Depositing User: Nur Farahin Ramli
Date Deposited: 24 Feb 2014 09:16
Last Modified: 28 Sep 2017 09:57
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3844/ajisp.2011.17.23
URI: http://psasir.upm.edu.my/id/eprint/24112
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