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Metabolomics for bioactivity assessment of natural products.


Nancy Dewi Yuliana, and Khatib, Alfi and Choi, Young Hae and Verpoorte, Robert (2011) Metabolomics for bioactivity assessment of natural products. Phytotherapy Research, 25 (2). pp. 157-169. ISSN 0951-418X; ESSN: 1099-1573


Natural products historically have been a rich source of lead molecules in drug discovery, based on their capability to create unique and diverse chemical structures. However, it is also true that the vast number of metabolites typically present in natural products and their huge dynamic range results in the loss of many possibly bioactive natural compounds, becoming an inextricable obstacle for drug development. Recently, new strategies which favour a holistic approach as opposed to the traditional reductionist methods used previously, have been introduced with the purpose of overcoming the bottlenecks in natural product research. This approach is based on the application of new technologies, including metabolomics, for example. Metabolomics allows a systematic study of a complex mixture such as a phytochemical preparation, which can be linked to observations obtained through biological testing systems without the need for isolating active principles. This may put drug discovery from natural products back in the limelight again. In this review paper, the description of some examples of successful metabolomics applications in several important fields related to drug discovery from natural sources aims at raising the potential of metabolomics in reducing the gap between natural products (NP) and modern drug discovery demand.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1002/ptr.3258
Publisher: John Wiley & Sons
Keywords: Bioactivity; Drug discovery; Metabolomics; Natural product
Depositing User: Nur Farahin Ramli
Date Deposited: 24 Feb 2014 02:16
Last Modified: 10 Dec 2015 02:13
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/ptr.3258
URI: http://psasir.upm.edu.my/id/eprint/24086
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