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Response surface modeling of processing parameters for the preparation of phytosterol Nanodispersions using an emulsification-evaporation technique.


Citation

Wai, Fun Leong and Kok, Whye Cheong and Lai, Oi Ming and Long, Kamariah and Che Man, Yaakob and Misran, Misni and Tan, Chin Ping (2011) Response surface modeling of processing parameters for the preparation of phytosterol Nanodispersions using an emulsification-evaporation technique. Journal of the American Oil Chemists' Society, 88 (5). pp. 717-725. ISSN 0003-021X; ESSN:1558-9331

Abstract

The purpose of this study was to optimize the production parameters for water-soluble phytosterol nanodispersions. Response surface methodology (RSM) was employed to model and optimize three of the processing parameters: mixing time (t) by conventional homogenizer (1–20 min), mixing speed (v) by conventional homogenizer (1,000–9,000 rpm) and homogenization pressure (P) by high-pressure homogenizer (0.1–80 MPa). All responses [i.e., mean particle size (PS), polydispersity index (PDI) and phytosterols concentration (Phyto, mg/l)] fitted well to a reduced quadratic model by multiple regressions after manual elimination. For PS, PDI and Phyto, the coefficients of determination (R 2) were 0.9902, 0.9065 and 0.8878, respectively. The optimized processing parameters were 15.25 min mixing time, 7,000 rpm mixing speed and homogenization pressure 42.4 MPa. In the produced nanodispersions, the corresponding responses for the optimized preparation conditions were a PS of 52 nm, PDI of 0.3390 and a Phyto of 336 mg/l.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1007/s11746-010-1714-7
Publisher: Springer Verlag
Keywords: Phytosterol; Nanodispersion; Response surface methodology; High-pressure.
Depositing User: Nur Farahin Ramli
Date Deposited: 31 Dec 2013 07:19
Last Modified: 09 Oct 2015 07:51
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s11746-010-1714-7
URI: http://psasir.upm.edu.my/id/eprint/22271
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