UPM Institutional Repository

Population genetic structure of Peninsular Malaysia Malay sub-ethnic groups


Wan Isa, Wan Nur Hatin and Ab Rajab, Nur Shafawati and Zahri, Mohd Khairi and Xu, Shuhua and Jin, Li and Tan, Soon Guan and Idid, Mohammed Rizman and Alwi, Zilfalil and The HUGO Pan-Asian SNP Consortium (2011) Population genetic structure of Peninsular Malaysia Malay sub-ethnic groups. PLOS ONE, 6 (4). art. no. e18312. pp. 1-5. ISSN 1932-6203


Patterns of modern human population structure are helpful in understanding the history of human migration and admixture. We conducted a study on genetic structure of the Malay population in Malaysia, using 54,794 genome-wide single nucleotide polymorphism genotype data generated in four Malay sub-ethnic groups in peninsular Malaysia (Melayu Kelantan, Melayu Minang, Melayu Jawa and Melayu Bugis). To the best of our knowledge this is the first study conducted on these four Malay sub-ethnic groups and the analysis of genotype data of these four groups were compiled together with 11 other populations' genotype data from Indonesia, China, India, Africa and indigenous populations in Peninsular Malaysia obtained from the Pan-Asian SNP database. The phylogeny of populations showed that all of the four Malay sub-ethnic groups are separated into at least three different clusters. The Melayu Jawa, Melayu Bugis and Melayu Minang have a very close genetic relationship with Indonesian populations indicating a common ancestral history, while the Melayu Kelantan formed a distinct group on the tree indicating that they are genetically different from the other Malay sub-ethnic groups. We have detected genetic structuring among the Malay populations and this could possibly be accounted for by their different historical origins. Our results provide information of the genetic differentiation between these populations and a valuable insight into the origins of the Malay sub-ethnic groups in Peninsular Malaysia.

Download File

[img] Text
Restricted to Repository staff only

Download (148kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1371/journal.pone.0018312
Publisher: Public Library of Science
Keywords: Molecular population genetics; SNP; Malays; Peninsular Malaysia
Depositing User: Nur Farahin Ramli
Date Deposited: 31 Dec 2013 04:27
Last Modified: 01 Oct 2019 06:12
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1371/journal.pone.0018312
URI: http://psasir.upm.edu.my/id/eprint/22267
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item