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Safety and clinical usage of Newcastle disease virus in cancer therapy.


Citation

Lam, Han Yuen and Yeap, Swee Keong and Rasoli, Mehdi and Omar, Abdul Rahman and Yusoff, Khatijah and Abd. Aziz, Suraini and Mohamed Alitheen, Noorjahan Banu (2011) Safety and clinical usage of Newcastle disease virus in cancer therapy. Journal of Biomedicine and Biotechnology, 2011 (718710). pp. 1-13. ISSN 1110-7243; ESSN: 1110-7251

Abstract

Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, specially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV stra ins applied for cancer immunotherapy is also discussed in this paper.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2011/718710
Publisher: Hindawi Publishing Corporation
Keywords: Newcastle disease virus (NDV); Cancer immunotherapy; Oncolytic viruses.
Depositing User: Najwani Amir Sariffudin
Date Deposited: 17 Jun 2014 01:10
Last Modified: 05 Oct 2015 02:40
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2011/718710
URI: http://psasir.upm.edu.my/id/eprint/22230
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