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Self built of laboratory scale supercritical anti solvent system


Citation

Chong, G. H. and R., Yunus and Choong, Thomas Shean Yaw and Abdullah, N. and Spotar, S. Y. (2010) Self built of laboratory scale supercritical anti solvent system. In: 9th Conference on Supercritical Fluids and Their Applications, 5-8 Sep. 2010, Sorrento, Italy. . (Unpublished)

Abstract / Synopsis

Supercritical fluid (SCF) particles formation technique gained a significant attention mainly in the pharmaceutical, cosmetic and paints. However, the scarcity of information on the design and process for this type of laboratory scale equipment is a significant drawback to the technological progress. Therefore, the purpose of this study was to design and build a laboratory supercritical anti solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The operating conditions of the constructed system affected the yield. The optimum operating conditions were then determined as: 110 bars, 35° C, 35 mg/ml of polymer concentration and 1.75 ml/min of feed flow rate. The microparticles and microcapsules were characterized on its morphology (scanning electron microscopy), size distribution (particle size analyzer), thermal properties (thermo gravimetetric analyzer) and crystallographic (X-ray powder diffraction). The in vitro drug released of the microparticles and microcapsules were also investigated. The results revealed a more homogenous microparticle size distribution, a change in the crystalinity and maintained of drug thermal stability after the SAS process. Furthermore, the microcapsules prolong the drug released significantly in the in vitro study.


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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Subject: Supercritical fluids
Subject: Solvents
Divisions: Faculty of Food Science and Technology
Keywords: Supercritical fluid; Anti solvent; SAS; Particle formation
Depositing User: Samsida Samsudin
Date Deposited: 25 Nov 2011 03:41
Last Modified: 05 Jan 2015 08:05
URI: http://psasir.upm.edu.my/id/eprint/18210
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