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Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate


Citation

Ravoof, Thahira B. S. A. and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Cowley, Andrew R. and Ali, Mohammad Akbar (2004) Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate. Polyhedron, 23 (16). pp. 2491-2498. ISSN 0277-5387

Abstract / Synopsis

New mixed-ligand complexes of general empirical formula, [Cu(NNS)(sac)(H2O)] (NNS′ = S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate, NNS″ = S-methyl-β-N-(2-acetylpyrid-2-yl)methylenedithiocarbazate and NNS‴ = S-methyl-β-N-(2-benzoylpyrid-2-yl) methylenedithiocarbazate, sac = the saccharinate anion) have been synthesized by reacting [Cu(sac)2(H2O)4] · 2H2O with the appropriate ligands in water–ethanol mixtures and characterized by elemental analysis and conductance, magnetic, IR and electronic spectroscopic measurements. Magnetic and spectral evidence support a five-coordinate geometry for the complexes in which the Schiff bases coordinate as NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor ligand. An X-ray crystallographic structural analysis of [Cu(NNS′)(sac)(H2O)] shows that the complex has a distorted square-pyramidal structure in which the Schiff base is coordinated to the copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulfur atom, the fourth and fifth coordination positions of the five-coordinate Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. The complexes have been evaluated for their biological activities against eight pathogenic microbials and human T-lymphoblastic leukemia cell lines. The complexes exhibit marked cytotoxicity against leukemic cell lines and display moderate activity against pathogenic bacteria and fungi.


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Additional Metadata

Item Type: Article
Subject: Chemistry, Inorganic chemistry
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/j.poly.2004.08.005
Publisher: Elsevier
Keywords: Cu(II) complexes, Dithiocarbazate Schiff base, Saccharin complexes, S-Methyldithiocarbazate, Tridentate NNS Schiff base
Depositing User: Najwani Amir Sariffudin
Date Deposited: 29 Sep 2011 09:07
Last Modified: 29 Oct 2015 06:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.poly.2004.08.005
URI: http://psasir.upm.edu.my/id/eprint/17745
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