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Anti cancer activity of mangiferin from methanol extract of fruit of Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.)


Ismail, Adawiah and Abdullah, Luqman Chuah and Pin, Kar Yong and Awang Biak, Dayang Radiah and Yusuf, Umi Kalsom and Ismail, Nor Fariza (2014) Anti cancer activity of mangiferin from methanol extract of fruit of Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.). In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. .


Phaleria macrocarpa (Scheff.) Boerl known as Mahkota Dewa is one of Indonesia's traditional medicines from family of Thymelaeaceae. Traditional medicine practitioners claim that the chemical compounds in mahkota dewa retains antihistamine, antioxidant and anti cancer effects. In this study, one compound has been successfully isolated from methanolic extract of Mahkota Dewa's fruit as single compound known as mangiferin. To ensure whether this compound; mangiferin contribute to the anti cancer activities, the cytotoxic effect on a breast cancer cell line; MCF-7, cervical cancer cell line; HeLa, and human colon adenocarcinoma cell; HT-29, was examined. The results show that Mahkota Dewa can be promising sources of natural products with potential anti cancer.

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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Engineering
Faculty of Science
Institute of Tropical Forestry and Forest Products
Publisher: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
Keywords: Phaleria macrocarpa (Scheff.) Boerl; Mahkota Dewa; Mangiferin; Anti cancer
Depositing User: Nabilah Mustapa
Date Deposited: 26 Apr 2016 04:09
Last Modified: 26 Apr 2016 04:09
URI: http://psasir.upm.edu.my/id/eprint/17166
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