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In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell


Citation

Chong, Hueh Zan and Rahmat, Asmah and Yeap, Swee Keong and Md. Akim, Abdah and Mohamed Alitheen, Noorjahan Banu and Othman, Fauziah and Ee, Gwendoline Cheng Lian (2012) In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell. BMC Complementary and Alternative Medicine, 12. art. no. 35. pp. 1-10. ISSN 1472-6882

Abstract / Synopsis

Background: Strobilanthes crispus has been traditionally used as antidiabetic, anticancer, diuretic, antilytic and laxative agent. However, cytotoxicity and antiproliferative effect of S. crispus is still unclear. Results: Strobilanthes cripus was able to reduce cell viability and proliferation in MTT and BrdU assays. Both cell cycle progression and Tunel assay suggested that IC50 of S. crispus ethanol extract induced sub-G1 cell cycle phase, and DNA fragmentation. On the other hand, translocation of mitochondria cytochrome c release, induction of caspase 3/7 and p53 while suppress XIAP on treated MCF-7 cell were also observed in this study. Conclusion: Our findings suggest that S. crispus ethanol extract induced apoptosis and DNA fragmentation on hormone dependent breast cancer cell line MCF-7 via mitochondria dependent p53 apoptosis pathway.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
Faculty of Science
DOI Number: https://doi.org/10.1186/1472-6882-12-35
Publisher: BioMed Central
Keywords: Apoptosis; MCF-7; P53; Strobilanthes crispus
Depositing User: Nabilah Mustapa
Date Deposited: 08 Apr 2016 11:49
Last Modified: 08 Apr 2016 11:49
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/1472-6882-12-35
URI: http://psasir.upm.edu.my/id/eprint/17144
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