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Solid lipid nanoparticles preparation and characterization.


Abdullah Al-Haj, Nagi Ahmed and Abdullah, Rasedee (2009) Solid lipid nanoparticles preparation and characterization. International Journal of Pharmacology, 5 (1). pp. 90-93. ISSN 1811-7775

Abstract / Synopsis

The presents study aimed to prepare and characterize Solid Lipid Nanoparticles (SLNs) from palm oil materials. Hydrogenated palm oil and lecithin incorporated with surfactant were mixed and formed by High Pressure Homogenization (HPH) at elevated temperature. Appropriate analytical methods are needed for the characterization of SLN. The use of several analytical techniques is a necessity such as particle size which determined using Photon Correlation Spectroscopy (PCS). The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and recrystallization behavior characterized by Differential Scanning Calorimetry (DSC). Data showed physical stability of the formulation. In conclusion, the SLN presented here are well suited for several applications including drug delivery.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number:
Publisher: ANSInet, Asian Network for Scientific Information
Keywords: Solid lipid nanoparticles; Transmission electron microscopy; High pressure homogenization; Differential scanning calorimetry; Photon correlation spectroscopy.
Depositing User: Azizan Arshad
Date Deposited: 19 Nov 2013 14:32
Last Modified: 27 Nov 2015 11:52
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