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Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity


Shameli, Kamyar and Ahmad, Mansor and Wan Yunus, Wan Md. Zin and Ibrahim, Nor Azowa and Abdul Rahman, Russly and Jokar, Maryam and Darroudi, Majid (2010) Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity. International Journal of Nanomedicine, 5. pp. 573-579. ISSN 1176-9114


In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller–Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.

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Additional Metadata

Item Type: Article
Subject: Nanocomposites (Materials)
Subject: Nanoparticles
Subject: Antibacterial agents
Divisions: Faculty of Science
DOI Number: https://doi.org/10.2147/IJN.S12007
Publisher: Dove Medical Press Ltd.
Keywords: Antibacterial activity; Silver nanoparticles; Biodegradable; Poly (lactic acid); Muller–Hinton agar
Depositing User: Najwani Amir Sariffudin
Date Deposited: 29 Jan 2013 10:11
Last Modified: 29 Jan 2013 10:11
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S12007
URI: http://psasir.upm.edu.my/id/eprint/16710
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