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Serotonergic properties of the roots of Clerodendron capitatum


Abdelwahab, Siddig Ibrahim and Mohamed, Abdel Wahab Hassan and Mohamed, Osama Yousif and Elhassan Taha, Manal Mohamed and Abdul, Ahmad Bustamam and Al-Zubairi, Adel Sharaf (2008) Serotonergic properties of the roots of Clerodendron capitatum. American Journal of Biochemistry and Biotechnology, 4 (4). pp. 425-430. ISSN 1553-3468; ESSN: 1558-6332


The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.

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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
DOI Number: https://doi.org/10.3844/ajbbsp.2008.425.430
Publisher: Science Publications
Keywords: 5-HT; Adrenergic; Cholinergic effects; Clerodendrum capitatum
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 14 May 2013 04:27
Last Modified: 04 Dec 2017 04:03
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3844/ajbbsp.2008.425.430
URI: http://psasir.upm.edu.my/id/eprint/16678
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