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Preliminary analysis of the antinociceptive activity of zerumbone


Sulaiman, Mohd Roslan and Perimal, Enoch Kumar and Zakaria, Zainul Amiruddin and Mokhtar, Fuzi and Akhtar, Muhammad Nadim and Lajis, Md Nordin and Israf Ali, Daud Ahmad (2009) Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia, 80 (4). pp. 230-232. ISSN 0367-326X


We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action.

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Additional Metadata

Item Type: Article
Subject: Analgesics
Subject: Plant extracts
Subject: Zingiberaceae
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/j.fitote.2009.02.002
Publisher: Elsevier
Keywords: Zerumbone; Antinociceptive; Acetic acid-induced abdominal constriction test; Hot plate test
Depositing User: Najwani Amir Sariffudin
Date Deposited: 29 Mar 2013 08:33
Last Modified: 29 Mar 2013 08:33
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.fitote.2009.02.002
URI: http://psasir.upm.edu.my/id/eprint/16295
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