Citation
Ee , Gwendoline Cheng Lian and Lim, Chyi Meei and Rahmani, Mawardi and Shaari, Khozirah and Bong, Choon Fah Joseph
(2010)
Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum.
Molecules, 15 (4).
pp. 2398-2404.
ISSN 1420-3049
Abstract
Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’- (methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science Faculty of Agriculture and Food Sciences |
| DOI Number: | https://doi.org/10.3390/molecules15042398 |
| Publisher: | MDPI |
| Keywords: | Piper nigrum; Pellitorine; Alkaloids; Cytotoxicity; Microbial transformation; Aspergillus niger. |
| Depositing User: | Najwani Amir Sariffudin |
| Date Deposited: | 22 Aug 2013 03:05 |
| Last Modified: | 10 Sep 2015 06:54 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules15042398 |
| URI: | http://psasir.upm.edu.my/id/eprint/16064 |
| Statistic Details: | View Download Statistic |
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