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Naturally occurring labdane diterpene and benzofuran from Globba pendula.


Maulidiani, H.M and Shaari , Khozirah and Paetz , ChristiaN and Stanslas, Johnson and Abas, Faridah and Lajis, Nordin (2009) Naturally occurring labdane diterpene and benzofuran from Globba pendula. Natural Product Communications, 4 (8). pp. 1031-1036. ISSN 1934-578X


Phytochemical investigation on Globba pendula resulted in the isolation of a new naturally occurring 16-oxo-(8)17-12-labdadien-15,11-olide 1 and benzofuran-2-carboxaldehyde 2. Other known compounds including isoandrographolide, indirubin, vanillin, vanillic acid, 2(3H)-benzoxazolone, as well as beta-sitosteryl-beta-D-glucopyranoside, beta-sitosterol, and 7alpha-hydroxysitosterol were also isolated. The structures were established based on spectroscopic data and comparison with the literature. Furthermore, the compound isoandrographolide has demonstrated strong cytotoxic properties towards a panel of cancer cell lines (MCF-7, PC-3, and H-460) with the IC50 values of 7.9, 8.7, and 9.0 microM, respectively.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Publisher: Natural Product Communications
Keywords: Globba pendula; Zingiberaceae; Labdane diterpene.
Depositing User: Khairil Ridzuan Khahirullah
Date Deposited: 22 May 2013 03:21
Last Modified: 22 May 2013 03:21
URI: http://psasir.upm.edu.my/id/eprint/15783
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