Citation
Sarmadi, Vahid Hosseinpour and Tong, Chih Kong and Vidyadaran, Sharmili and Abdullah, Maha and Seow, Heng Fong and Ramasamy, Rajesh
(2010)
Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest.
Medical Journal of Malaysia, 65 (3).
pp. 202-207.
ISSN 0300-5283
Abstract
We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV173 and Jurkat tumour cells, the proliferation of tumour cells were profoundly inhibited in a dose dependent manner mainly via cell to cell contact interaction. Further cell cycle analysis reveals that MSC arrest tumour cell proliferation in G0/G1 phase of cell cycle thus preventing the entry of tumour cells into S phase of cell cycle.
Download File
Official URL or Download Paper: http://www.e-mjm.org/2010/v65n3/index.html
|
Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| Publisher: | Malaysian Medical Association |
| Keywords: | Apoptosis; Cell cycle arrest; Mesenchymal stem cells; Proliferation; Tumour cells |
| Depositing User: | Raja Norazlinda Raja Azenam |
| Date Deposited: | 04 Jul 2013 00:35 |
| Last Modified: | 09 Aug 2017 08:11 |
| URI: | http://psasir.upm.edu.my/id/eprint/15613 |
| Statistic Details: | View Download Statistic |
Actions (login required)
 |
View Item |