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Intestinal microsporidiosis: a new entity in Malaysia?


Awang Hamat, Rukman and Osman, Malina and M. I., Noorhayati and Mohammad, Marlyn and Abdullah, Wan Omar and Abd. Majid, Roslaini and Unyah, Ngah Zasmy and Moktar, Norhayati (2008) Intestinal microsporidiosis: a new entity in Malaysia? Malaysian Journal of Medicine and Health Sciences, 4 (2). pp. 11-24. ISSN 1675-8544


Objective: Intestinal microsporidia is an emerging human disease caused by microsporidia. A study was conducted to determine the prevalence of microsporidia in patients with gastro-intestinal symptoms and to examine the clinical manifestations associated with intestinal microsporidiosis. Methods: A descriptive cross-sectional study using a well-structured questionnaire; a review of medical records was also undertaken. Positive stool samples were defined as presence of one or more pinkish-violet ovoid structures with a belt-like stripe under high power field (100x) using modified gram-chromotrope stain (MGC). Results: A total of 353 faecal specimens of patients was examined and 100 patients were found to have positive stool samples for microsporidia. The overall prevalence of microsporidia was 28.3%. Acute and chronic diarrhoea were seen in 49.0% and 36.0% patients, respectively. The commonest clinical presentations were diarrhoea (85.0%) with 83.0 % of patients having loose or watery stools, vomiting (75.0%), foul-smelling stools (60.0%), nausea (59.0%) and cramping abdominal pain (39.0%). The least common symptoms were fever (15.0%), mucous in stool (5.0%) and blood in stool (4.0%). Conclusion: This study concludes that the prevalence of microsporidia is still high (28.3%) and the majority of patients (93.0%) are symptomatic; the most common gastro-intestinal symptom is diarrhoea with loose or watery stools. Hence, it is recommended that a stool screening for microsporidia be done in selected patients presented with gastrointestinal symptoms.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Intestinal microsporidia; Gastrointestinal symptom; Modified gramchromotrope stain; Diarrhoea; Loose; Watery stool
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 17 Oct 2013 03:02
Last Modified: 07 Oct 2015 07:35
URI: http://psasir.upm.edu.my/id/eprint/15281
Statistic Details: View Download Statistic

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