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Hepatoprotective and antioxidant action of Moringa oleifera lam. againsts acetaminophen induced hepatoxicity in rats.


Citation

Fakurazi, Sharida and Nanthini, Uma and Ithnin, Hairuszah (2008) Hepatoprotective and antioxidant action of Moringa oleifera lam. againsts acetaminophen induced hepatoxicity in rats. International Journal of Pharmacology, 4 (4). pp. 270-275. ISSN 1811-7775 : ESSN: 1812-5700

Abstract

This study is conducted to investigate the possible hepatoprotective action of Moringa oleifera Lam. (MO), a high value medicinal plant against a single high dose of APAP induced hepatotoxicity. Male Sprague Dawley rats were dosed with APAP (3000 mg kg-1 body weight; p.o.) to induce hepatocellular damage. In rats that were pretreated with MO (200 and 800 mg kg-1, p.o.) for 14 days prior to APAP treatment there was a reduction of liver enzymes (ALT, AST and ALP) and also the restoration of glutathione level. The biochemical results showed parallel finding with the histopathological analysis in which liver sections obtained from rats pretreated with MO, the damage was blocked. Intriguingly, MO alone has significantly elevated the level glutathione compared to the control group. The findings has suggested that Moringa oleifera Lam. is a promising product in protecting the liver against APAP induced liver injury via the restoration and elevation of glutathione level in the liver.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3923/ijp.2008.270.275
Publisher: Asian Network for Scientific Information (ANSINET)
Keywords: Acetaminophen; Glutathione; Hepatoprotective; Hepatotoxicity; Moringa oleifera; Paracetamol.
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 17 Oct 2013 08:27
Last Modified: 06 Oct 2015 07:14
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/ijp.2008.270.275
URI: http://psasir.upm.edu.my/id/eprint/14997
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