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Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity


Fakurazi, Sharida and Ithnin, Hairuszah and Jabit, Mohd Lip and Ganabadi, Shanti and Nanthini, Uma and Abdul Rahman, Shamima and Abd Hamid @ Abdul Razak, Roslida and Tan, Y. H. (2009) Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity. Journal of Medical Sciences, 9 (3). pp. 161-164. ISSN 1682-4474; ESSN: 1812-5727


This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. Group I was administered with 0.2% zerumbone for 14 days prior to 3 g kg-1 paracetamol administration. Group II was given paracetamol early and group III was given 200 mg kg-1 of silymarin and paracetamol. Group IV was administered with zerumbone only and finally group V was treated with corn oil and 40% sucrose buffer as vehicle treated group. Animals were sacrificed at 4 and 24 h post treatment following diethyl ether. There was no significant changes in liver enzyme activities as well as histological observations at 4 h after paracetamol administration. Meanwhile, 24 h after paracetamol administration, the level of alanine aminotransferase (ALT), aspartate aminotransferase. (AST) and alkaline phosphatase (ALP) were found to be reduced in rats that were pretreated with zerumbone compared to group that was treated with paracetamol only. Correspondingly, there was no hepatocellular necrosis observed in rats that were pretreated with zerumbone. The results obtained may have suggested that zerumbone exert hepatoprotective activities against paracetamol induced hepatotoxicity.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.3923/jms.2009.161.164
Publisher: Asian Network for Scientific Information
Keywords: Acetaminophen; Hepatotoxicity; Paracetamol; Zingiber zerumbet
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 17 Oct 2013 08:23
Last Modified: 28 Oct 2016 02:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/jms.2009.161.164
URI: http://psasir.upm.edu.my/id/eprint/14996
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