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Gene expression of CDK6 and CCND1 genes in basal cell carcinoma


Eshkoor, Sima Ataollahi and Ismail, Patimah and Abdul Rahman, Sabariah (2008) Gene expression of CDK6 and CCND1 genes in basal cell carcinoma. Journal of Medical and Biological Sciences, 2 (2). pp. 1-9. ISSN 1934-7189


Basal cell carcinoma (BCC) is the most common cancer among skin cancers. Cell cycle deregulation in G1-phase is a critical event during the course of carcinogenesis, which is probably much more important than other phases of cell cycle, during the course of skin carcinogenesis. CCND1 and CDK6 are important components of Retinoblastoma regulatory pathway in arrest and uncontrolled proliferation of cell cycle. To determine the expression pattern of CDK6, CCND1 in BCC, this study involved ten samples of paraffin embedded of BCC tissues. Two selected normal skin tissue were investigated using RT in situ PCR and Immunohistochemistry (IHC) techniques. Nuclear and cytoplasmic staining intensity of samples within tumor cells and normal tissue illustrated a different mRNA and protein expression. This study represents significant expression of CCND1 and CDK6 genes in BCC (alpha level is 0.05). CDK6 and CCND1 mRNA, and protein of these genes are expressed to induce the cell cycle proliferation and the influence proliferation of cell cycle and BCC.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Global Commerce & Communication
Keywords: Cancer; Skin cancer; CCND1 gene; Basal cell carcinoma
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 31 Jul 2015 06:56
Last Modified: 15 Sep 2015 01:16
URI: http://psasir.upm.edu.my/id/eprint/14862
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