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GC/MS determination of bioactive components and antibacterial properties of Goniothalamus umbrosus extracts


Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam and Elhassan Taha, Manal Mohamed and Mohan, Syam and Ibrahim, Mohamed Yousif and Mariod, Abdalbasit Adam and Abdullah Al-Haj, Nagi Ahmed and Abdullah, Rasedee (2009) GC/MS determination of bioactive components and antibacterial properties of Goniothalamus umbrosus extracts. African Journal of Biotechnology, 8 (14). art. no. 339E80715928. pp. 3336-3340. ISSN 1684–5315

Abstract / Synopsis

In this study, the antibacterial activity and chemical composition of Goniothalamus umbrosus leaves extracts were evaluated. The antibacterial activity was investigated using two gram-positive bacteria, Methicillin resistant Staphylococcus aureus (MRSA) and Bacillus subtilis B29, and two gram-negative bacteria,Pseudomonas aeruginosa 60690 and Salmonella choleraesuis. The activity was tested using disc diffusion and minimum inhibitory concentration assays. The chemical compositions of the ethyl acetate extract of G. umbrosus were investigated using Shimadzu gas chromatography–mass spectrometry (GC-17A) while the mass spectra of the compounds found in the extract was matched with the library. The results showed that the extracts demonstrated broad spectrum antibacterial effects against all tested bacteria. GC/MS analysis of ethyl acetate extract of G. umbrosus revealed the existence of 1-butyl-2-cyclohexen-1-ol (46.84%), benzaldehyde (4.42%) and globulol (4.07%). The results of this study offer a platform of using G. umbrosus as herbal alternative for the current synthetic antimicrobial agents.

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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Faculty of Medicine and Health Science
Publisher: Academic Journals
Keywords: Goniothalamus umbrosus; GC/MS; Antibacterial properties
Depositing User: kmportal
Date Deposited: 06 Dec 2013 10:24
Last Modified: 09 Nov 2017 13:34
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