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Factors associated with abdominal obesity among HIV-infected adults on antiretroviral therapy in Malaysia


Hejazi, Nazisa and Huang, Mary Soo Lee and Khor, Geok Lin and Lee, Christopher Kwok Choong (2010) Factors associated with abdominal obesity among HIV-infected adults on antiretroviral therapy in Malaysia. Global Journal of Health Science, 2 (2). pp. 20-31. ISSN 1916-9736; ESSN: 1916-9744


Abdominal or central obesity is a common morphological alteration among HIV-infected subjects on antiretroviral treatment. There is concern that this condition places the subjects at risk of cardiovascular disease. This is a cross-sectional study of 334, HIV-infected adult subjects on antiretroviral therapy at a public hospital in Malaysia. It was aimed at determining the association between nutritional factors and abdominal obesity among PLHIV receiving antiretroviral treatment. Abdominal obesity was prevalent in 36.5% of the respondents. Respondents with abdominal obesity were significantly (p<0.05) older in age, had significantly higher blood triglycerides, fasting plasma glucose, lower HDL-cholesterol, higher BMI at the start of medication and also at the time of the study, bigger waist circumference, higher waist hip ratio, body fat mass, systolic and diastolic blood pressure. They also had lower mean CD4 cell count at start of medication and body lean mass than those without abdominal obesity. After adjusting for the covariates, a significant higher risk of abdominal obesity were observed in those who were older (adjusted OR=1.053, CI=1.012-1.095), had higher fasting plasma glucose (adjusted OR=1.189, CI=1.014-1.394), higher BMI at the time of study (adjusted OR=1.426, CI=1.215-1.674). Being Malay was a protective factor (adjusted OR=0.264, CI=00.102-0.685) for abdominal obesity. These results suggest that care of the HIV-infected population must include intervention to address abdominal obesity in order to provide better quality of life.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.5539/gjhs.v2n2p20
Publisher: Canadian Center of Science and Education
Keywords: Abdominal obesity; HIV/AIDS; ARV treatment; Nutrition; Dietary intake; Waist-hip ratio; Malaysia
Depositing User: Nabilah Mustapa
Date Deposited: 09 Apr 2019 03:46
Last Modified: 09 Apr 2019 03:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5539/gjhs.v2n2p20
URI: http://psasir.upm.edu.my/id/eprint/14698
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