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Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.


Yam, Mun Fee and Ang, Lee Fung and Basir, Rusliza and Salman, Muhammad Ibrahim and Ameer, Omar Ziad and Asmawil, Mohd Zaini (2009) Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. Inflammopharmacology, 17 (1). pp. 50-54. ISSN 0925-4692; ESSN: 1568-5608


The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD 50 of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s10787-008-8038-3
Publisher: Springer Verlag
Keywords: 3′-hydroxy-5,6,7,4′-tetramethoxyflavone; Antipyretic effect; Eupatorin; Orthosiphon stamineus; Rosmarinic acid; Sinensetin.
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 08 Nov 2013 09:00
Last Modified: 04 Nov 2015 02:52
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s10787-008-8038-3
URI: http://psasir.upm.edu.my/id/eprint/14613
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