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Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study


Citation

Abbasi, Sakineh and Azimi, Cyrus and Othman, Fauziah and Daloii, Mohammad Reza Noori and Ashtiani, Zahra Ousati and Mojarrad, Majid and Oskouei, S. A. and Nejad, F. M. and Ismail, Patimah (2009) Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study. Trends in Molecular Sciences, 1 (1). pp. 1-10. ISSN 1994-5469; ESSN: 2077-2270

Abstract

A case study was conducted to establish a database of polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive breast tumors, (150 patients) and in healthy individuals (147 healthy control individuals). PCR single-strand conformation polymorphism methodology and direct sequencing were performed. The silent single nucleotide polymorphism (SNPs) was performed, as reported previously in other studies, but at significantly different frequencies, with further increasing predictive accuracy in Iranian population. Data suggest that ESR1 polymorphisms are correlated with various aspects of breast cancer in Iranian ESR1 genotype, as determined during pre-surgical evaluation, might represent a surrogate marker for predicting breast cancer.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3923/tms.2009.1.10
Publisher: Asian Network for Scientific Information
Keywords: Estrogen receptor polymorphisms; LN metastases; SSCP-PCR
Depositing User: Nabilah Mustapa
Date Deposited: 08 Apr 2019 08:53
Last Modified: 08 Apr 2019 08:53
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/tms.2009.1.10
URI: http://psasir.upm.edu.my/id/eprint/14575
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