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Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.


Citation

Ismail, Amin and Koh, B. K. and Rahmat, Asmah (2004) Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. Journal of Medicinal Food, 7 (1). pp. 7-12. ISSN 1096-620X; ESSN: 1557-7600

Abstract

This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes-alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities-in plasma and/or liver of hepatocarcinogenic rats, which were induced with diethylnitrosamine and 2-acetylaminofluorene. Twenty-nine male Sprague-Dawley rats (weighing 150-330 g) were divided into four groups (n = 6-8): normal control group (N), normal group + CLE (NE), cancer group (C), and cancer group + CLE (CE). Analysis of variance showed significant differences (P < .05) in the specific activities of ALP, GGT, and GST between the C and N groups. However, GR activity for the C group was not significantly different compared with the N group. In the CE group, the specific activities of ALP, GGT, GST, and GR were significantly lower (P < .05) compared with the C group. The findings showed that CLE could lower the activity of tumor marker enzymes of rats during hepatocarcinogenesis. Based on the results obtained, polyphenol compounds present in the cacao liquor, extracted by using ethanol, have the potential in decreasing the severity of hepatocarcinogenesis.


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Official URL or Download Paper: http://online.liebertpub.com/loi/JMF

Additional Metadata

Item Type: Article
DOI Number: https://doi.org/10.1089/109662004322984635
Publisher: Mary Ann Liebert
Keywords: Cacao liquor; Hepatocarcinogenesis; Tumor marker enzymes.
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 07 Mar 2014 01:16
Last Modified: 02 Oct 2015 01:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1089/109662004322984635
URI: http://psasir.upm.edu.my/id/eprint/14208
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