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Cytotoxic Aaptamines from Malaysian Aaptos aaptos.


Shaari, Khozirah and Kee, Cheng Ling and Mat Rashid, Zalilawati and Tan, Pei Jean and Abas, Faridah and Mohd Raof, Salahudin and Zainal, Zurina and Lajis, Nordin and Mohamad, Habsah and Ali, Abdul Manaf (2009) Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Marine Drugs, 7 (1). pp. 1-8. ISSN 1660-3397


In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.3390/md7010001
Publisher: MDPI
Keywords: Marine sponge; Aaptos aaptos; Aaptaminoids; Alkaloids; Cytotoxicity.
Depositing User: Khairil Ridzuan Khahirullah
Date Deposited: 06 Nov 2013 03:37
Last Modified: 06 Nov 2013 03:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/md7010001
URI: http://psasir.upm.edu.my/id/eprint/13851
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