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Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum


Ismail, Intan Safinar and Nagakura, Yuta and Hirasawa, Yusuke and Hosoya, Takahiro and Mohd Lazim, Mohd Izwan and Lajis, Md. Nordin and Shiro, Motoo and Morita, Hiroshi (2009) Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum. Journal of Natural Products, 72 (10). pp. 1879-1883. ISSN 0163-3864 & Online ISSN: 1520-6025


Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Institute of Bioscience
DOI Number: https://doi.org/10.1021/np9003849
Publisher: American Society of Pharmacognosy & American Chemical Society
Keywords: Chrotacumines A-D; Chromone alkaloids; Dysoxylum acutangulum
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 09 Jun 2015 00:58
Last Modified: 29 Sep 2015 02:06
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1021/np9003849
URI: http://psasir.upm.edu.my/id/eprint/13595
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