UPM Institutional Repository

Chemical constituents and antimicrobial activity of Goniothalamus macrophyllus (Annonaceae) from Pasoh Forest Reserve, Malaysia


Ab Ghani, Siti Humeirah and Mohtar, Mastura and Mohamad Ali, Nor Azah and Jamil, Mailina and J. A., Saiful and Hamid, Muhajir and Abdullah, Mohd Puad (2010) Chemical constituents and antimicrobial activity of Goniothalamus macrophyllus (Annonaceae) from Pasoh Forest Reserve, Malaysia. African Journal of Biotechnology, 9 (34). art. no. 69CB0E332566. pp. 5511-5515. ISSN 1684–5315


The essential oils from the twig and root of Goniothalamus macrophyllus were obtained by hydrodistillation and subjected to Gas Chromatography (GC-FID) and Gas Chromatography/Mass Spectrometry (GC-MS) using CBP-5 capillary column in order to determine their chemical composition. Both twig and root oils and four reference standard compounds (α-pinene, linalool, geraniol and geranyl acetate) were evaluated for their antimicrobial properties against gram positive and gram negative bacteria, yeast and dermatophyte fungi using broth microdilution methods. The GCMS analysis revealed twenty-one and fourteen compounds from twig and root oils which represented 90.0 and 42.5% of the total oils, respectively. The oils were found to possess the following major components: twig: geranyl acetate (45.5%), geraniol (17.0%), linalool (12.7%) and camphene (7.5%); root: cyperene (9.8%), geranyl acetate (9.4%), geraniol (3.4%) and linalool (2.6%). Other components present in appreciable amounts in both essential oils were α-pinene (0.8%) and benzaldehyde (0.5%). The root oil exhibited the most notable inhibitory activity (0.3 mg/ml) against Vancomycin intermediate-resistance Staphylococcus aureus (VISA 24), Staphylococcus epidermidis and Candida albicans. α-pinene meanwhile inhibited the bacteria and fungal growth at 0.3 and 2.5 mg/ml. With regards to antimicrobial potential, α-pinene superceeds linalool, geraniol and geranyl acetate, respectively.

Download File

[img] PDF
Restricted to Repository staff only

Download (142kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
Publisher: Academic Journals
Keywords: α-pinene; Annonaceae; Antimicrobial activity; Cyperene; Essential oils; Geraniol; Geranyl acetate; Goniothalamus macrophyllus; Linalool
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 14 May 2014 06:01
Last Modified: 09 Nov 2017 04:37
URI: http://psasir.upm.edu.my/id/eprint/13568
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item