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Biological activities of Pereskia bleo extracts


Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam and Mohan, Syam Murali and Al-Zubairi, Adel Sharaf and Elhassan Taha, Manal Mohamed and Ibrahim, M. Y. (2009) Biological activities of Pereskia bleo extracts. International Journal of Pharmacology, 5 (1). pp. 71-75. ISSN 1811-7775; ESSN: 1812-5700


The aim of this study is to screen the hexane, dicholoromethane, ethyl acetate and methanol extracts of Pereskia bleo (PB) for their antibacterial, anti-oxidant and anti-cancer properties using disc diffusion method, DPPH assay and MTT cytotoxicity test, respectively. It is found that hexane and methanol extracts showed highly and moderately, respectively, considerable antibacterial activity towards two Gram-negative bacteria, P. aeruginosa 60690 and S. choleraesuis. Ethyl acetate extract showed a week narrow spectrum activity (= 35% of streptomycin activity). The highest antibacterial activity on MRSA is obtained by DCM extract. Hexane extract was the most effective DPPH radical scavenger (37.55%). Ethyl acetate and DCM extracts were less effective free radical scavenger (16.1%). None of the extracts were cytotoxic significantly towards MCF-7, HT-29 and CEM-SS cell lines after 72 h incubation time (IC50 > 30 μg mL-1). It could be concluded that antibacterial activity of P. bleo is the most promising biological activity attributed to this plant.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3923/ijp.2009.71.75
Publisher: Asian Network for Scientific Information
Keywords: Anti-oxidant; Anti-tumor; Antibacterial; Pereskia bleo
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 14 Nov 2014 00:56
Last Modified: 19 Nov 2015 08:52
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/ijp.2009.71.75
URI: http://psasir.upm.edu.my/id/eprint/13416
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