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Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana


Md. Sukari, Mohd Aspollah and Tang, Sook Wah and Md Saad, Suhaila and Rashid, Nur Yuhasliza and Rahmani, Mawardi and Lajis, Md. Nordin and Yap, Taufiq Yun Hin (2010) Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana. Natural Product Research, 24 (9). pp. 838-845. ISSN 1478-6419; ESSN: 1029–2349


Curcuma ochrorhiza ('temu putih') and C. heyneana ('temu giring') are two Zingiberaceous species which are commonly used in traditional medicine in Malaysia and Indonesia. Phytochemical investigations on these Curcuma species have resulted in the isolation of six sesquiterpenes, namely zerumbone (1), furanodienone (2), zederone (3), oxycurcumenol epoxide (4), curcumenol (5) and isocurcumenol (6), along with phytosterols stigmasterol and alpha-sitosterol. Compounds 1 and 2 were obtained for the first time for C. ochrorhiza while 4 was new to C. heyneana. The hexane extract of C. ochrorhiza and sesquiterpenes 1 and 3 showed very strong cytotoxicity activity against T-acute lymphoblastic leukaemia cells (CEM-SS), with IC(50) values of 6.0, 0.6 and 1.6 microg mL(-1), respectively. Meanwhile, constituents from C. heyneana (4-6) demonstrated moderate inhibition against CEM-SS in cytotoxic assay, with IC(50) values of 11.9, 12.6 and 13.3 microg mL(-1), respectively. The crude extracts and sesquiterpenes isolated were moderately active against certain bacteria tested in antimicrobial screening.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1080/14786410903052951
Publisher: Taylor & Francis
Keywords: Curcuma ochrorhiza; Curcuma heyneana; Sesquiterpenes; Cytotoxic; Antimicrobial
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 08 Jun 2015 04:17
Last Modified: 29 Nov 2016 01:35
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/14786410903052951
URI: http://psasir.upm.edu.my/id/eprint/13401
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