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Attenuation of cisplatin-induced hepatotoxicity in rats using zerumbone.


Ibrahim, Mohammed Yousif and Abdul, Ahmad Bustamam and Abdel Wahab, Siddig Ibrahim and Elhassan Taha, Manal Mohamed and Al Zubairi, Adel Sharaf and Syam Mohan, Murali Mohan (2009) Attenuation of cisplatin-induced hepatotoxicity in rats using zerumbone. Research Journal of Biological Sciences, 4 (7). pp. 777-784. ISSN 1815-8846; ESSN: 1993-6087


Zerumbone is a natural compound isolated from the fresh rhizomes of Zingiber zerumbet. This bioactive compound has shown a chemo-preventive, anti-inflammatory and free radical scavenging activities. This study examines, the effect of zerumbone on the extent of tissue damage in Cisplatin-induced hepatotoxicity in rats. The rats received a single dose injection of 45 mg kg-1 Cisplatin. Other groups of rats received zerumbone (100 and 200 mg kg-1), corn oil or the vehicle (DMSO) intraperitoneally for 4 days prior to Cisplatin injections. All animals were decapitated 16 h after Cisplatin injection. Trunk blood was collected and analyzed for alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase and gama-glutamyl transferase. Liver tissue was kept for the quantification of malondialdehyde and glutathione levels. Histopathological investigations were carried out and severity of lesions was scored to obtain quantitative data. This study revealed that zerumbone reduced the extent of liver damage and preserved liver functions as proved by microscopic observations and lesion scoring. Increase in liver MDA levels with a simultaneous reduction in GSH in the Cisplatin 45 mg kg-1 group was attenuated by zerumbone treatment (p<0.05). Zerumbone is beneficial in Cisplatin-induced liver dysfunction and organ damage in rats via prevention of lipid peroxidation and preservation of antioxidant glutathione.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
Publisher: Medwell Journals
Keywords: Zerumbone; Cisplatin; Lliver injury; Oxidative stress; Antioxidant gluthatione; Lipid peroxidation
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 14 Nov 2014 01:31
Last Modified: 29 Sep 2015 06:14
URI: http://psasir.upm.edu.my/id/eprint/13325
Statistic Details: View Download Statistic

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