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Antinociceptive activity of the essential oil of Zingiber zerumbet.


Sulaiman, Mohd Roslan and Tengku Mohamad, Tengku Azam Shah and Shaik Mossadeq, Wan Mastura and Moin, Saidi and Mohd Yusoff, Mazina and Mokhtar, Ahmad Fauzi and Zakaria, Zainul Amiruddin and Israf Ali, Daud Ahmad and Lajis, Nordin (2010) Antinociceptive activity of the essential oil of Zingiber zerumbet. Planta Medica, 76 (2). pp. 107-112. ISSN 0032-0943; ESSN: 1439-0221


In the present study, the rhizome essential oil from Zingiber zerumbet (Zingiberaceae) was evaluated for antinociceptive activity using chemical and thermal models of nociception, namely, the acetic acid-induced abdominal writhing test, the hot-plate test and the formalin-induced paw licking test. It was demonstrated that intraperitoneal administration of the essential oil of Z. zerumbet (EOZZ) at the doses of 30, 100 and 300mg/kg produced significant dose-dependent inhibition of acetic acid-induced abdominal writhing, comparable to that of obtained with acetylsalicylic acid (100mg/kg). At the same doses, the EOZZ produced significant dose-dependent increases in the latency time in the hot-plate test with respect to controls, and in the formalin-induced paw licking test, the EOZZ also significantly reduced the painful stimulus in both neurogenic and inflammatory phase of the test. In addition, the antinociceptive effect of the EOZZ in the formalin-induced paw licking test as well as hot-plate test was reversed by the nonselective opioid receptor antagonist, naloxone suggesting that the opioid system was involved in its analgesic mechanism of action. On the basis of these data, we concluded that the EOZZ possessed both central and peripheral antinociceptive activities which justifying its popular folkloric use to relieve some pain conditions.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1055/s-0029-1185950
Publisher: Georg Thieme Verlag
Keywords: Antinociceptive activity; Essential oil; Opioid system; Zingiber zerumbet; Zingiberaceae
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 06 Dec 2014 02:27
Last Modified: 06 Dec 2014 02:27
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1055/s-0029-1185950
URI: http://psasir.upm.edu.my/id/eprint/13163
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