Antileukemic activity and chemical constituents of some Zingiberaceae species

Citation

Md.Sukari, Mohd. Aspollah and Tang, Sook Wah and Neoh, Bee Keat and Ee, Gwendoline Cheng Lian and Rahmani, Mawardi (2010) Antileukemic activity and chemical constituents of some Zingiberaceae species. Asian Journal of Chemistry, 22 (10). pp. 7891-7896. ISSN 0970-7077; ESSN: 0975-427X

Abstract

Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44 %) were found to have cytotoxic activity with IC50 values less than 30 μg/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides b-sitosterol.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
Publisher:	Chemic Publishing Company
Keywords:	Zingiberaceae; Antileukemic; Alpinia; Zingiber; Kaempferia
Depositing User:	Nurul Ainie Mokhtar
Date Deposited:	30 Jul 2015 00:42
Last Modified:	20 Oct 2015 23:47
URI:	http://psasir.upm.edu.my/id/eprint/13155
Statistic Details:	View Download Statistic

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