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Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.


Sulaiman, Mohd Roslan and Perimal, Enoch Kumar and Akhtar, Muhammad Nadeem and Tengku Mohamad, Tengku Azam Shah and Khalid, Mohamed Hanief and Tasrip, Nor Asmara and Mokhtar, Fuzi and Zakaria, Zainul Amiruddin and Lajis, Nordin and Israf Ali, Daud Ahmad (2010) Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81 (7). pp. 855-858. ISSN 0367-326X; ESSN: 1873-6971


The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1016/j.fitote.2010.05.009
Publisher: Elsevier
Keywords: Anti-inflammatory activity; Carrageenan-induced paw edema test; Cotton pellet-induced granuloma test; Zerumbone
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 06 Dec 2014 04:12
Last Modified: 06 Dec 2014 04:12
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.fitote.2010.05.009
URI: http://psasir.upm.edu.my/id/eprint/13154
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