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Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems


Zakaria, Zainul Amiruddin and Tengku Mohamad, Tengku Azam Shah and Chai, Teng Chear and Wong, Y. Y. and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2010) Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems. Medical Principles and Practice, 19 (4). pp. 287-294. ISSN 1011-7571; ESSN:1423-0151


OBJECTIVE: The present study was carried out to determine the antiinflammatory and antinociceptive activities of a methanol extract of Zingiber zerumbet rhizomes (MEZZ) using various experimental model systems. MATERIALS AND METHODS: The MEZZ was prepared by macerating oven-dried (50 degrees C) powdered rhizomes (1.2 kg) of Z. zerumbet in 80% methanol in a ratio of 1:20 (w/v) for 48 h. The supernatant was collected, filtered and evaporated to dryness under reduced pressure (50 degrees C) yielding approximately 21.0 g of the crude dried extract. The crude dried extract was stored at -20 degrees C prior to use and was dissolved in normal saline (0.9% NaCl) immediately before administration at concentrations required to produce doses of 25, 50 and 100 mg/kg. RESULTS: All dosages of MEZZ showed significant (p < 0.05) antiedema activity when assessed using the carrageenan-induced paw edema test and the cotton-pellet-induced granuloma test. The MEZZ exhibited significant (p < 0.05) antinociceptive activity when assessed by the writhing, hot plate and formalin tests. Pretreatment with naloxone (5 mg/kg) significantly decreased the latency of discomfort produced by the 100 mg/kg dose of MEZZ in the hot plate test. CONCLUSION: MEZZ produced antiinflammatory and antinociceptive activities which may involve the inhibition of bradykinin-, prostaglandin-, histamine- and opioid-mediated processes.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1159/000312715
Publisher: Karger
Keywords: Zingiber zerumbet; Methanol extract; Antiinflammatory activity; Antinociceptive activity
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 18 Jan 2016 08:37
Last Modified: 18 Jan 2016 08:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000312715
URI: http://psasir.upm.edu.my/id/eprint/13150
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