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Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf


Citation

Abd Hamid @ Abdul Razak, Roslida and Tay, C. E. and Ahmad, Zuraini and Chan, Pit Foong (2010) Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf. Journal of Natural Remedies, 10 (2). pp. 97-104. ISSN 0972-5547; ESSN: 2320-3358

Abstract

Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Informatics Publishing Limited and Natural Remedies
Keywords: Acetic acid induced writhing; Annona muricata; Carrageenan-induced oedema
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 06 Dec 2014 05:07
Last Modified: 14 Aug 2017 09:13
URI: http://psasir.upm.edu.my/id/eprint/13148
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