UPM Institutional Repository

Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils


Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul and Abd. Kadir, Arifah and Hussain, Mohd Khairi and Sulaiman, Mohd Roslan and Teh, Lay Kek and Salleh, Mohd. Zaki and Long, Kamariah (2010) Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils. African Journal of Pharmacy and Pharmacology, 4 (9). pp. 636-644. ISSN 1996-0816


Virgin coconut oil (VCO), or in Malays known as ‘minyak kelapa dara’, has gain a lot of attention recently due to various medicinal values. The aim of the present study was to evaluate the effect of feeding two types of VCOs, VCOA (produced via a standard drying method) or VCOB (prepared via fermentation process), that were produced by Malaysia Agriculture Research and Development Institute (MARDI) in lowering the plasma lipid parameter in rabbits. Nine groups of New Zealand White male rabbits (n = 6/group) were used in this study. Group 1 and 2 animals were treated with 0.9% normal saline, but fed either with a normal or cholesterol-added diet (negative control), respectively. Group 3 - 5 and 6 - 8 were given orally with the different volume (0.5, 1.0 and 2.5 ml/kg/day) of VCOA or VCOB followed by the cholesterol-added diet. Group 9 were treated with 5 mg/kg Atorvastatin and fed a cholesterol-added diet. All groups were treated for 8 weeks and blood samples were taken from the marginal ear vein prior to treatment (day 0), weeks 4 and 8 for the analysis of plasma. The rabbits fed with different volume of VCOs showed significant (P < 0.05) reduction in plasma cholesterol and LDL cholesterol levels compared to the control group in weeks 4 and 8. The triglycerides level increased significantly (P < 0.05) on week 4 before reduced on week 8, to a level that is still significant when compared to week 0. The HDL level also increased significantly (P < 0.05) on weeks 4 and 8 after treatment. Fatty acid analysis revealed the presence of all important fatty acids. Both VCOs showed insignificant effect on all parameters measured when compared together. In conclusion, the MARDI-produced VCOs appeared to possess great potentials as antihypercholesterolemic agent that required further in-depth study.

Download File

PDF (Abstract)
Antihypercholesterolemia property and fatty acid composition of MARDI.pdf

Download (152kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Publisher: Academic Journals
Keywords: Virgin coconut oil; Antihypercholesterolemia; Atorvastatin
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 07 Jun 2015 03:52
Last Modified: 24 Nov 2015 03:42
URI: http://psasir.upm.edu.my/id/eprint/13144
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item