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Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss


Citation

Mohan, Syam and Abdul, Ahmad Bustamam and Abdelwahab, Siddiq Ibrahim and Al-Zubairi, Adel Sharaf and Sukari, Mohd Aspollah (2008) Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss. Journal of Pharmacology and Toxicology, 3 (6). pp. 449-456. ISSN 1816-496X; ESSN: 2152-100X

Abstract

Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T flagelliforme in these cancers. The purpose of the present study was to investigate the potential m vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Institute of Bioscience
DOI Number: https://doi.org/10.3923/jpt.2008.449.456
Publisher: Academic Journals
Keywords: Typhonium flagelliforme; Cancer; Apoptosis; Leukaemia; CEM-ss
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 07 Jun 2015 03:12
Last Modified: 23 Oct 2015 06:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/jpt.2008.449.456
URI: http://psasir.upm.edu.my/id/eprint/13140
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