Chemical composition, total phenolics and antioxidant activities of crude leaf extract from Clinacanthus nutans (Burm. f.)

Clinacanthus nutans (Burm. f.), one of the important species in the Acanthaceae family, is utilized as an essential herbal remedy and is located in tropical Asia. This plant contains a wide variety of beneficial chemicals, according to a phytochemical analysis. The objective of this research is to examine the phytochemical phenols, flavonoids, and antioxidant activity of Clinacanthus nutans leaf extract. Total carbohydrates (71.05±0.09%), crude protein (12.32±0.09%), moisture (6.91±0.01%), and fat content (1.01±0.01%) were the main nutrients in the leaf that were measured. At 500, 1000, and 2000 mg/mL, the 2,2'-diphenyl-1-picrylhydrazyl (DPPH)% inhibition of crude methanolic leaf extract was significantly lower than that of ascorbic acid; at the same dosages, the ABST% inhibition of methanolic leaf extract was lower than that of butylated hydroxytoluene (BHT). At a 2000 mg/ml dosage, leaf extract significantly increased total phenol (17.47±0.61 mg GAE/g) and flavonoid (8.23±0.11 mg RU/g) compared to 1000 and 500 mg/ml. It has been reported that 12 phenolic compounds, including 4 phenolic acid compounds, 5 flavonoids, and 3 unknown chemicals, were found using liquid chromatography with mass spectrometry (LC-MS/MS). The results demonstrate that increasing concentrations of methanolic leaf extract improves antioxidant capacity against various reactive oxygen species. Understanding the traditional use of herbal medicines, preserving them for future use, and safeguarding them for good purposes all depend on an understanding of their photochemistry.

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