Acyl chain length modulates the digestion of sn-1,3 diacylglycerols: a systematic investigation from physicochemical properties to molecular interactions

Citation

Ke, Wanting and Liu, Hiu Tung and Ye, Yiheng and Lee, Yee Ying and Tan, Chin Ping and Xu, Mingchen and Wang, Yong and Zhang, Zhen (2026) Acyl chain length modulates the digestion of sn-1,3 diacylglycerols: a systematic investigation from physicochemical properties to molecular interactions. Food Chemistry, 522. art. no. 149995. pp. 1-13. ISSN 0308-8146; eISSN: 1873-7072

Abstract

Sn -1,3 diacylglycerols ( sn -1,3 DAGs) are functional lipids with health benefits, but the mechanism by which acyl chain length regulates their digestion remains unclear. This study was conducted to elucidate how acyl chain length governs the in vitro digestion pathway and efficiency of sn -1,3 DAGs. Four saturated sn -1,3 DAGs (C10, C12, C16, C18) were prepared and their in vitro digestion was investigated via gastrointestinal simulation, lipolysis kinetics, and molecular docking. Acyl chain length strongly affected digestive efficiency, medium-chain DDAG and LDAG showed near-complete lipolysis (100% and 99.10%), while long-chain PDAG and SDAG exhibited much lower values (52.04% and 39.71%). LDAG exhibiting the highest apparent first-order rate constant (0.182 s−1). PDAG displayed the strongest enzyme binding affinity (−8.8351 kcal/mol) but not higher hydrolysis. These results support the rational design of structured lipids with tailored digestive properties for nutritional applications.

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Additional Metadata

Item Type:	Article
Subject:	Analytical Chemistry
Subject:	Food Science
Divisions:	Faculty of Food Science and Technology
DOI Number:	https://doi.org/10.1016/j.foodchem.2026.149995
Publisher:	Elsevier Ltd
Keywords:	Acyl chain length; In vitro digestion; Lipolysis kinetics; Molecular docking; Sn-1,3 diacylglycerol
Sustainable Development Goals (SDGs):	SDG 3: Good Health and Well-being, SDG 12: Responsible Consumption and Production, SDG 2: Zero Hunger
Depositing User:	Ms. Siti Radziah Mohamed@mahmod
Date Deposited:	14 Jul 2026 09:13
Last Modified:	14 Jul 2026 09:13
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.foodchem.2026.149995
URI:	http://psasir.upm.edu.my/id/eprint/126791
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