Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice

Background: Psoriasis, also known as Psoriasis (Pso), is a persistent skin disorder characterized by erythematous, indurated, scaly, itchy, and often painful plaques. Although conventional medicine has been employed to treat psoriasis, it may cause adverse effects owing to its long-term use. Consequently, alternative medicine has become a popular option to address this issue. Coffee liberica pulp, a commonly overlooked waste product, has been found to have numerous benefits for humans. Aim: This study investigated the effectiveness of Liberia coffee pulp extract using an imiquimod (IMQ)-induced mouse model that replicated several features of psoriasis in humans. Methods: The study involved applying IMQ cream and other topical treatments to the shaved dorsal skin of mice. The psoriasis Area and Severity Index score, body weight, organ weight, expression of interleukins in the skin and serum, and full blood count were measured. Results: The results showed significant changes (p < 0.05) in skin weights in the negative control group compared with other groups. No significant changes in other organ weight were observed in any groups. However, the full blood count revealed significant changes (p < 0.05) in haemoglobin and white blood cell counts. The levels of interleukin 17a, interleukin 22, and interleukin 23 levels showed significant differences (p < 0.05) between the positive and treatment groups. Conclusion: This study found that C. liberica pulp has anti-inflammatory and antioxidant properties that help reduce skin inflammation. These findings suggest that C. liberica is a cost-effective source of natural antioxidants that can be used to alleviate psoriasis.

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